Two sample MR report
SMDT1_Monocyte (Mono) against finn-b-ASTHMA_ALLERG_EXMORE
Date: 13 January, 2026
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 11 | -0.0648552 | 0.1052106 | 0.5528800 |
| Weighted median | 11 | -0.0407643 | 0.0198039 | 0.0395516 |
| Inverse variance weighted | 11 | -0.0364925 | 0.0165903 | 0.0278332 |
| Simple mode | 11 | -0.0474369 | 0.0310874 | 0.1580155 |
| Weighted mode | 11 | -0.0431110 | 0.0306535 | 0.1899131 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 3.593789 | 9 | 0.9360612 |
| Inverse variance weighted | 3.668316 | 10 | 0.9610720 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| 0.0169112 | 0.061947 | 0.7910174 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 0.000763 | 0 | TRUE | 0.0085512 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
